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 The Role of Complexin in Regulated Exocytosis. A Study Shows that the SNARE-binding Protein Complexin is a Positive Regulator of Vesicle Priming in Fast, Calcium-triggered Exocytosis
Наименование:

The Role of Complexin in Regulated Exocytosis. A Study Shows that the SNARE-binding Protein Complexin is a Positive Regulator of Vesicle Priming in Fast, Calcium-triggered Exocytosis

автор haijiang c. издательство Книга по Требованию Органическая химия
Cтраниц 132        мягкая обложка       
Аннотация:This work has studied the role of complexin in regulated exocytosis, a key mechanism underlies hormone and neurotransmitter release and understanding of which will help to design therapeutic interventions in a lot of neuronal diseases or endocrine diseases. Overexpression of wildtype CPX II ? but not of SNARE-binding-deficient mutants -- restores the size of the readily releasable pool in knockout cells, and in wildtype cells it markedly enlarges the readily releasable pool. These results suggest that CPXs prime vesicles for exocytosis and, therefore, are positive regulators of Ca2+-triggered exocytosis. The work shows that adrenal chromaffin cells from CPX II knockout mice exhibit a markedly diminished readily releasable vesicle pool, while showing no change in the kinetics of fusion pore dilation or morphological vesicle docking. The work here systematically dissects the vesicle stages leading up to exocytosis using a knockout-rescue strategy in a mammalian model system.
Автор: haijiang c.
Издательство: Книга по Требованию
Год:2008
Цена:
2415 руб
Нет в наличии
Поиск: The Role of Complexin in Regulated Exocytosis. A Study Shows that the SNARE-binding Protein Complexin is a Positive Regulator of Vesicle Priming in Fast, Calcium-triggered Exocytosis


ДОСТИГ ЦЕЛИ, А СЧАСТЬЕ НЕ НАСТУПИЛО?


Formation of group behaviour in the organisations

Ide ifica io is co ec ed wi h forma io of feeli g of a accessory of he i dividual o group. his process proceeds a hree levels: he emo io al as abili y o empa hize. How abili y o become o he poi of view of o her perso or all group a d behavioural? As aspira io o obey o developi g group orms. I egra io marks i self a s age whe he race for power i group is already fi ished, group orms, roles of everyo e ha is whe associa io of i dividuals has ur ed o i dividual collec ive are fi alised. I egra io leads o ra sforma io of collec ive i o he self-regula ed social orga ism well adap ed for i commo -i dividual ac ivi y. For he give s age of developme of group followi g sig s are charac eris ic: he purposes are accura ely desig a ed; compa ibili y of i dividuals i group is reached; he leader of group has proved he righ o leadership i prac ice; he group successfully carries ou he problems pu before i ; he size of group allows o k ow opi io of i s each member a d o es ima e i . People feel he accessory o group, ha g oge her, overcomi g i commo difficul ies a d solvi g group problems. Co flic s a d he s resses show a he begi i g i is especially freque a d pai ful, arise all less of e a d are resolved i he mos spari g ways wi h par icipa io of all group.
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