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 B, Aryl Hydrocarbon Receptor and Xenobiotics via Pregnane X Receptor Mechanistic Studies of Drug-Disease and Drug-Drug Interactions. Regulation of CYP3A4 Gene Expression by NF-?
Наименование:

B, Aryl Hydrocarbon Receptor and Xenobiotics via Pregnane X Receptor Mechanistic Studies of Drug-Disease and Drug-Drug Interactions. Regulation of CYP3A4 Gene Expression by NF-?

автор Xinsheng G. издательство Книга по Требованию Основы социологии
Cтраниц 140        мягкая обложка       
Аннотация:Drug metabolism is initially a defensive mechanism driven by certain enzymes to facilitate excretion and in turn reduce the body burden of the absorbed xenobiotics. Every minute, we are exposed to and involuntarily absorb xenobiotics which may produce beneficial outcomes or harmful effects on our bodies. However, the capacity of this protective system is regulated by factors including disease states, absorbed xenobiotics and genetic factors. Cytochrome P450 3A4 (CYP3A4) is the most abundant phase I drug metabolism enzyme in human liver and its expression levels affect the capacity of drug metabolism. This book also introduces basic knowledge of xenobiotics and their disposition, drug metabolizing systems, nuclear receptors as xenosensors, as well as inflammation and NF-? B. The information provided is useful to professionals and students in the fields of pharmaceuticals, pharmacy, medicinal therapeutics, chemical risk assessment and related scientific research. In this book, mechanisms have been investigated on regulation of CYP3A4 gene expression through modulating pregnane X receptor transcriptional activity under inflammation and by xenobiotics.
Автор: Xinsheng G.
Издательство: Книга по Требованию
Год:2009
Цена:
2415 руб
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Поиск: B, Aryl Hydrocarbon Receptor and Xenobiotics via Pregnane X Receptor Mechanistic Studies of Drug-Disease and Drug-Drug Interactions. Regulation of CYP3A4 Gene Expression by NF-?



The practice of modern medicine

Cli ical pharmacology has led o he developme of more effec ive drugs a d o he ide ifica io of adverse reac io s. More rece ly es ablished medical special ies are hose of preve ive medici e, physical medici e a d rehabili a io , family prac ice, a d uclear medici e. I he U i ed S a es every medical specialis mus be cer ified by a board composed of members of he special y i which cer ifica io is sough . Some ype of peer cer ifica io is required i mos cou ries. Expa sio of k owledge bo h i dep h a d i ra ge has e couraged he developme of ew forms of rea me ha require high degrees of specializa io , such as orga ra spla a io a d excha ge ra sfusio ; he field of a es hesiology has grow i creasi gly complex as equipme a d a es he ics have improved. ew ech ologies have i roduced microsurgery, laser beam surgery, a d le s impla a io (for ca arac pa ie s), all requiri g he specialis 's skill. Precisio i diag osis has markedly improved; adva ces i radiology, he use of ul rasou d, compu erized axial omography (CA sca ), a d uclear mag e ic reso a ce imagi g are examples of he ex e sio of ech ology requiri g exper ise i he field of medici e. o provide more efficie service i is o u commo for a specialis surgeo a d a specialis physicia o form a eam worki g oge her i he field of, for example, hear disease.
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