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 Imidazoline Receptors in Insulin Signaling and Metabolic Regulation. Molecular Basis for I1-imidazoline Binding and Cell Signaling and the Mechanisms Linking this Signaling Protein to Regulation Glucose Metabolism
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Imidazoline Receptors in Insulin Signaling and Metabolic Regulation. Molecular Basis for I1-imidazoline Binding and Cell Signaling and the Mechanisms Linking this Signaling Protein to Regulation Glucose Metabolism

издательство Книга по Требованию Книги
Cтраниц 212        мягкая обложка       
Аннотация:IRAS is a gene candidate for the I1-imidazoline receptor. Antisense transfection reduced specific imidazoline radioligand binding to plasma membrane fractions with parallel drops in IRAS protein expression. Furthermore, transfection with antisense caused functional impairment of I1-imidazoline receptor signaling without affecting basal ERK level or ERK activation by growth factors. These results implicate adipose tissue as a locus of insulin resistance in this model of metabolic syndrome. These findings strongly suggested that IRAS encodes an I1-imidazoline receptor or at least an important subunit of it. The mechanism of insulin sensitizing effect from imidazolines was studied in the SHROB rat. Insulin induced glucose uptake in these cells from SHROB were also similarly resistant to insulin stimulation. Chronic treatment of SHROB with moxonidine partially restored both Akt activation and glucose uptake stimulated by insulin in isolated abdominal adipocytes without affecting basal Akt activation level. Akt activation was found to be severely impaired in isolated adipocytes from SHROB. Antisense oligo-nucleotides were designed and transfected into PC12 cells.
Издательство: Книга по Требованию
Год:2008
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3233 руб
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Поиск: Imidazoline Receptors in Insulin Signaling and Metabolic Regulation. Molecular Basis for I1-imidazoline Binding and Cell Signaling and the Mechanisms Linking this Signaling Protein to Regulation Glucose Metabolism
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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