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 Receptor recognition and virus entry pathways Receptor Specificity and Cellular Entry of Human Rhinoviruses.
Наименование:

Receptor recognition and virus entry pathways Receptor Specificity and Cellular Entry of Human Rhinoviruses.

автор Abdul G.A.B. издательство Книга по Требованию Общая биология
Cтраниц 140        мягкая обложка       
Аннотация:However, this virus entry is dependent on functional dynamin and viruses accumulate in comparatively larger vesicular structures. Here we provide evidence that there is a increasing trend for the involvement of heparan sulfate (HS) proteoglycans as an alternate receptor. Human rhinoviruses (HRVs), the major cause of the common cold, are classified into two groups on the basis of receptor specificity. Combining immunofluorescence technique with electron microscopy, dominant negative mutants and pharmacological inhibitor assays, we demonstrate that the major group virus (HRV14) enters via dynamin- independent macropinocytosis into RD-ICAM cells whereas virus entry into RD cells via HS exhibits similar characteristics with respect to co- localization with endocytic markers and pharmacological inhibitor profiles. Concerning virus entry, where minor group HRVs depend on clathrin-mediated endocytosis, the pathway of major group HRVs and that of HS-binding viruses is largely unknown. Minor group HRVs use members of the low-density lipoprotein receptor (LDLR) super-family while major group types bind to intercellular adhesion molecule-1 (ICAM-1).
Автор: Abdul G.A.B.
Издательство: Книга по Требованию
Год:2010
Цена:
2415 руб
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Поиск: Receptor recognition and virus entry pathways Receptor Specificity and Cellular Entry of Human Rhinoviruses.
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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