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 Immunfunktion unter ALL-Therapie ~ prospektive Studie an 23 Kindern. Untersuchungen der Zytokinproduktion und der T-Zellregeneration mittels Durchflusszytometrie, TRECS, Immunoscope und ELISA
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Immunfunktion unter ALL-Therapie ~ prospektive Studie an 23 Kindern. Untersuchungen der Zytokinproduktion und der T-Zellregeneration mittels Durchflusszytometrie, TRECS, Immunoscope und ELISA

автор Verena W. издательство Книга по Требованию Ветеринарный справочник традиционных и нетрадиционных методов лечения
Cтраниц 128        мягкая обложка       
Аннотация:Eine zytostatische Therapie hat neben der erwuenschten Wirkung auf leukaemische Blasten auch negative Folgen auf die Immunitaet. Ziel dieser Studie war es, die Immunfunktion von Kindern unter Chemotherapie quantitativ zu erfassen. Bei 23 Kindern (im Median 5Jahre) mit B- Vorlaeufer-ALL wurden unter Therapie gemaess ALL-BFM 2000 zu mehreren Zeitpunkten Lymphozytenuntergruppen bestimmt sowie die zellulaere Zytokinproduktion nach in vitro Stimulation gemessen. Die Zahl peripherer T-Zellen schwankte proportional zur Therapieintensitaet, es kam zu einer Verschiebung der CD4: Das T- und insbesondere auch das B- Zellsystem erfaehrt unter Chemotherapie tiefgreifende Veraenderungen. Dies sollte bei der Steuerung der Supportivtherapie (Prophylaxen, Impfungen) beruecksichtigt werden. Im Laufe der Therapie kam es zu einer Zunahme der IFNg Produktion durch T-Zellen (Diagnose: 11%, Tag 33: 22%). Eine Behandlung im Dexamethasonarm wirkte sich negativ auf die IFNg Produktion aus. Am ausgepraegtesten war eine andauernde B-Zelldepletion bis in die Dauertherapie hinein. CD8 Ratio zugunsten der CD8 T- Zellen. NK-Zellen zeigten keine signifikanten Veraenderungen.
Автор: Verena W.
Издательство: Книга по Требованию
Год:2010
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2415 руб
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Поиск: Immunfunktion unter ALL-Therapie ~ prospektive Studie an 23 Kindern. Untersuchungen der Zytokinproduktion und der T-Zellregeneration mittels Durchflusszytometrie, TRECS, Immunoscope und ELISA
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
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