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 Mass Spectrometry Studies of DNA-Directed Alkylating Agents. The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument
Наименование:

Mass Spectrometry Studies of DNA-Directed Alkylating Agents. The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument

автор Amin M.S.A.M. издательство Книга по Требованию Книги
Cтраниц 584        мягкая обложка       
Аннотация:Such approach is useful and has great potential in aiding DNA targeted drug design in terms of assessing the ligand DNA cross-linking ability, sequence specificity and to certain extent, degree of reactivity for a particular binding site. It can provide detail insights into the chemistry of drug-DNA interactions at high level of accuracy and sensitivity. This work is focused on the use of Mass Spectrometry based technique to determine the site of drug binding and to observe the chemical reactions that occur during ligand-DNA interaction. Mass spectrometry has many advantages in comparison to the conventional techniques applied in DNA targeted drug design. This work is part of a wider effort in developing drugs that target the minor groove region of the DNA which has been known to be invisible to DNA repair enzymes, a common problem that leads to cancer drug resistance.
Автор: Amin M.S.A.M.
Издательство: Книга по Требованию
Год:2010
Цена:
3050 руб
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Поиск: Mass Spectrometry Studies of DNA-Directed Alkylating Agents. The Study of Drug Binding Position on the DNA using MALDI and ESI Mass Spectrometry Instrument
НОВЫЙ ГОД СИМВОЛ 2013 ГОДАУКРАШЕНИЯ
КАРНАВАЛ НА НОВЫЙ ГОД РАСПРОДАЖА
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Прагматический анализ

Редукционистские эпистемологические программы, пытающиеся вывести значение фактуальных предложений в терминах "наблюдаемых", обнаруживаемых логических последовательностей оказываются, с такой точки зрения, беспредметными. Возможность одновременного наличия нескольких конфликтующих версий мира не отменяет и не уменьшает их истинностного значения (для разных концептуальных схем). Аналогичным образом признание относительности истинности языкового выражения не отрицает необходимости выявления четких критериев его правильности, в качестве которых могут выступать критерии адекватности правилам конструктивной системы. Это означает, что признание конвенциональности значения не подразумевает с необходимостью признание его произвольности. Fodor J., LePore E. Holism: A Shopper"s Guide. Ox., 1992. . Goodma . he S ruc ure of Appeara ce. 1s edi io : Cambridge Mass., 1951. 3rd edi io : Dordrech , 1987. . Goodma . he S ruc ure of Appeara ce. Cambridge Mass ., 1951. P .  57. Список литературы
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