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Патогенез Анестезия на основе пропофола в значительно меньшей степени усиливает прооксидантные процессы и снижает антиоксидантный потенциал. Минимальное смещение окислительно-антиоксидантного гомеостаза в эксперименте, как при хирургической травме, так и без неё выявлено при анестезии пропофолом. В клинике на всех этапах хирургической травмы пропофол в меньшей степени вызывает нарастание продуктов ПОЛ, снижение антиоксидантного потенциала организма, что позволяет рассматривать его как протекторный вид анестетика. Результаты исследований стали патогенетическим обоснованием необходимости коррекции выявленных нарушений окислительно-антиоксидантного гомеостаза. Введение рекомбинантной СОД в эксперименте приводит к повышению активности СОД, как при анестезии эфиром, тиопенталом натрия, кетамином, пропофолом, так и при сочетании этих видов обезболивания с лапаротомией. Ключевые слова: хирургическая травма, обезболивание, свободнорадикальные процессы. Summary Germa K.B. Free radical processes i pa hoge esis of failures caused by surgical rauma u der differe ki ds of a aes he iza io . – A ma uscrip . Disser a io for he ca dida e of medical scie ce degree i speciali y 14.03.04 – pa hologic physiology. – Kharkiv a io al Medical U iversi y. – Kharkiv, 2008. he role of free radical processes i pa hoge esis of failures caused by surgical rauma u der differe ki ds of a aes he iza io has bee s udied. he s udy allows o es ablish ha a aes hesiological aid by differe ki ds of a aes he ics such as hiope al a rium, ke ami , propofol is followed by free radical progress which is charac erized by i e sifyi g of oxida phe ome a, i crease of co ce ra io of lipid peroxide oxida io produc s as well as reduce of a ioxida ive po e ial. | |
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