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Reward Intermediate Vocabulary and Grammar Workbook without key

автор Greenall S. издательство Macmillan Publishers Иностранные языки
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Автор: Greenall S.
Издательство: Macmillan Publishers
Год:1998
Цена:
492 руб
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Клонирование и анализ генов легких цепей иммуноглобулинов...

Обозначения: - сигнальные олигомеры, фланкирующие V и J сегменты.резкого сокращения количества C генов. В-третьих, подобная организация позволяет упростить регуляцию экспрессии различных локусов. Ключевым принципом функционирования иммунной системы является принцип клональной селекции иммунокомпетентных клеток, несущих рецептор определенной специфичности. Ряд косвенных данных позволяет считать, что у акул гуморальный иммунный ответ клонально ограничен (Sha key a d Clem, 1980). Однако неизвестно, каким образом и насколько эффективно осуществляется это ограничение (Flaj ik, 1996). У млекопитающих принцип “одна клетка - одно антитело” обеспечивается благодаря изотипическому и аллельному исключению. При сегментарной организации генов продуктивная перестройка в одном из локусов ведет к блокированию перестройки других локусов и, тем самым к их инактивации. Однако, в случае наличия множественных VJC кластеров, в части из которых VJ сегменты слиты в зародышевой ДНК, механизмы контроля выборочной экспрессии могут быть более сложными или не столь эффективными.
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