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Клініко-патогенетичне обґрунтування корекції порушення обміну кальцію в лікуванні хворих на... Включение в терапию больных остеоартрозом с артериальной гипертензией глутаргина стимулирует образование эндотелиального оксида азота, что приводит к увеличению адекватности механизмов регуляции гомеостаза кальция, уменьшает интенсивность костной резорбции, улучшает суточный ритм артериального давления, не снижая эффективности лечения суставного синдрома. Ключевые слова: остеоартроз, артериальная гипертензия, обмен кальция, минеральная плотность костной ткани, оксид азота, индапамид, глутаргин. A O A IO Simbir seva K.Y. Cli ical a d pa hoge e ic subs a ia io of calcium me abolism disorder correc io of herapy i pa ie s wi h os eoar hri is a d ar erial hyper e sio . - A ma uscrip . he disser a io for ob ai i g a scie ific degree of he Ca dida e of Medical Scie ces o a speciali y 14.01.12 – rheuma ology. - Do e sk a io al Medical U iversi y amed by M. Gorky Heal h Mi is ry of Ukrai e, Do e sk, 2008. he disser a io is focused o s udyi g cli ical, pa hoge e ic a d herapeu ic fea ures of course of os eoar hri is wi h co comi a ar erial hyper e sio ha are show by calcium me abolism disorders, decreased bo e mi eral de si y, e do helial i ric oxide deficie cy a d cha ges of 24-hour blood pressure profile. herapy wi h i dapamide op imizes calcium bala ce, s imula es e do helial sy hesis of i ric oxide, decreases bo e issue remodeli g, improves car ilage fu c io a d has a sig ifica a ihyper e sive effec . | |
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